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The book contains reviews regarding the pathogenesis of Type-1 Diabetes. Type-1 Diabetes is a classic autoimmune disease. Genetic factors are responsible but they cannot describe the rapid, even overwhelming magnitude of this disease. It is important to comprehend etiology and pathogenesis of this disease. Several veterans in this field have analyzed a number of topics for consideration that are appropriate for clinicians as well as researchers alike. The book gives appropriate elucidation of advanced technologies and applications in the constant search for cure and treatments for diabetes. The topics are grouped under the sections: Pathogenesis, Pathogenesis-Virus, Pathogenesis-Environment, Imaging and Therapy.