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The book contains reviews regarding the pathogenesis of Type-1 Diabetes, which is a classic autoimmune disease. Genetic factors are responsible but they cannot describe the rapid, even overwhelming extent of this disease. It is important to comprehend etiology and pathogenesis of this disease. The complexities related to Type-1 Diabetes include a number of clinical problems. Several veterans in this field have analyzed a number of topics for consideration that are appropriate for clinicians as well as researchers alike. The book has been organized under two sections: Diabetes Onset and Cardiovascular Complications.