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This book focuses on educating radiologists, radiation oncologists and others interested in imaging research about how to design and conduct clinical trials to evaluate imaging technology and imaging biomarkers. * Presents a multi-disciplinary description of how to design and conduct clinical trials of imaging and image-guided interventions * Based on the popular didactic sessions presented at the annual "Clinical Trials Methodology Workshop" conducted for radiologists, radiation oncologists and imaging scientists, sponsored by the Radiological Society of North America (RSNA) * Written by internationally renowned editors and authors * Coverage includes principles of technology assessment, specific topic areas of clinical research in imaging, and various quantitative methods for designing and analyzing imaging clinical trials