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Natural Computing is the fascinating new field that has resulted from the improbable interplay between computer science and the natural sciences. It is the field of research that explores human-designed computing inspired by nature, such as artificial immune systems inspired by natural immune systems or evolutionary computation inspired by Darwinian evolution of species. In addition, the field also covers computation occurring naturally in the world around us, such as the computational nature of bacterial communication, biochemical reactions, developmental processes and brain processes. Handbook of Natural Computing, comprised of two volumes, thoroughly documents all the developments in this relatively young and fascinating multidisciplinary field. It is an important text for researchers in academia and industry as well as students in both computer science and biology.