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Using Biostatistics to Break the Barriers of Adopting New Medicines. This book covers from an advanced leading edge point of view the options for different methods in an HTA. For each statistical option, the link to regulatory and reimbursement decisions are made. The book provides a gentle no formula introduction to common statistical methods and real life examples. The book answers the questions why are some drugs and technologies granted regulatory or reimbursement approval and others are not? What can be done to improve the chance of approval?