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A new comprehensive analysis of human cardiovascular control explains the control of pressure, vascular volume, and blood flow during orthostasis and exercise, two stresses that most affect these variables. Analysis of the physical properties of the vascular system and their modification by mechanical, neural, and humoural factors is highlighted by novel graphical representations of basic concepts. Interactive effects of the vasculature on cardiac performance andfactors that both control and limit oxygen transfer from lungs to cells are stressed.