Modern Therapeutics in Rheumatic Diseases

Leading clinicians and clinical researchers discuss in practical detail the newest treatments used in rheumatic diseases, emphasizing-without neglecting current standard treatments-those experimental therapies now undergoing clinical trials and poised for early introduction into the rheumatology armamentarium. The diseases and therapeutic regimes examined here range from rheumatoid arthritis and its treatment by gene therapy, to osteoarthritis and systemic autoimune diseases. Each chapter is organized so that the busy clinician can quickly obtain all the information needed optimal patient treatment. This includes an analysis of the pathogenic mechanisms that explain the molecular basis of the newer therapeutics, reviews of animal data and the results of clinical trials, and recommendations concerning use, side effects, and precautions. The last decade has witnessed enormous progress in our understanding of the molecular and cellular processes that lead to rheumatic diseases and has seen the development and introduction of many novel biologics and drugs. In Modern Therapeutics in Rheumatic Diseases, leading clinicians and clinical researchers discuss in practical detail the newest treatments used in rheumatic diseases, emphasizing-without neglecting currently standard treatments-those experimental therapies now undergoing clinical trials and poised for early introduction into the rheumatology armamentarium. The diseases and therapeutic regimes examined here range from osteoarthritis and systemic autoimmune diseases to rheumatoid arthritis and its treatment by gene therapy. Each chapter is organized so that the busy clinician can quickly obtain all the information needed for optimal patient treatment. This information includes an analysis of the pathogenic mechanisms that explain the molecular basis of the newer therapeutics; reviews of animal data and the results of clinical trials; and recommendations concerning use, side effects, and precautions. §Authoritative and state-of-the-art, Modern Therapeutics in Rheumatic Diseases outlines the rapidly growing body of knowledge emerging from today's cutting-edge research, and shows how these therapeutic breakthroughs are now becoming practical standards of care for the active rheumatologist.