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Molecular Analysis of DNA Rearrangements in the Immune System
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154 b
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V(D)J recombination and heavy chain gene class switching constitute the two major DNA recombination processes, complemented by somatic hpyermutation, which generate the antigen receptor repertoire of the immune system. This volume describes recent research breakthroughs and offers a comprehensive overview. The advances described include the identification of several individual proteins acting at the initial steps in V(D)J recombination, and detailed insights into the formation and structure of recombination inter- mediates. The molecular investigation of class switch recom- bination got fresh input from the creation of in vivo and in vitro assays. The book includes a description of the third mechanism for increasing the antigen receptor diversity, somatic hpyermutation which has attracted renewed attention.
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