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Comprehensive look at the§latest research in the role of non-neuronal cells - astrocytes,§oligodendrocytes, endothelial cells, pericytes, microglia, and other§immune cells - in ischemic brain injury and long-term recovery. In these§cases, neurodegeneration and brain repair are controlled in a§sophisticated system, incorporating interactions between different cell§types and cellular systems. Explore the therapeutic strategies that§targets non-neuronal responses after stroke and discuss their§translational potentials.