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The physical principles that play a role in the biology of chemoreception are the focus of this book, which uses ideas from diffusion theory, statistical mechanics and hydrodynamics to develop mathematical models for some of the basic phenomena. The reader is expected to be familiar with the basics of differential and integral calculus. The book will be of use to theoretical physicists or applied mathematicians who want to work on biological problems, and to mathematically-inclined biologists. The author has used this material to teach students who are in their 3rd and 4th year of a study in physical engineering.