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Diabetes mellitus is a chronic disease characterized by elevated blood glucose levels and disturbances in carbohydrate, fat and protein metabolism. The treatment of diabetes with synthetic drugs is costly and chances of side effects are high. Phytomedicine has been used since ancient times in various parts of the world where access to modern medicine is limited. Medicinal plants and phytoconstituents play an important role in the management of diabetes mellitus especially in developing countries where resources are meager. Phytochemicals identified from medicinal plants present an exciting opportunity for the development of new types of therapeutics for diabetes mellitus. Most prevalent among phytochemical groups are the alkaloids, glycosides, polysaccharides, and phenolics such as flavonoids, terpenoids and steroids. This study provide a comparative information about the constituents of Centella asiatica, Phyllanthus niruri, Morus indica and Trigonella foenum-graecum (leaves and seeds) and its effect in sugar level reduction invitro.