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In this second special issue on signal transduction§leading specialists in their fields again present overviews§of topics related to the highly topicalsubject of signal§transduction. The first contribution, by Keppler, deals with§the biosynthesis, transport, inactivation, and analysis of§leukotrienes. Mohr et al. present an excellent overview of§the biology of the peptide hormone oxytocin and its role in§signal transduction.The review by Holzer describes the§significance of peptinergic sensory neurons in the control§of vascular functions. In the contribution by Wolf etal§the molecular biology of the Y chromosome is discussed.