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The genetic dissection of human primary immunodeficiency isexpanding at full speed, in at least two directions. Someinvestigators pursue the dissection of well-known clinicalphenotypes, for which the count of genetic etiologies seems to beendless, whereas others begin the search for inborn errorsunderlying new phenotypes, infectious and otherwise. The field ofprimary immunodeficiency is also expanding in other ways, with newtherapeutic approaches, and with the care of patients in regions ofthe world where these diseases were unheard of less than a decadeago. The volume provides an overview of the field of medicalgenetics and its progress in 2011. Volume I opens with a dialog between the volume editors on thedefinition of primary immunodeficiencies (PIDs); additional papers in this volume focus on PIDs in Latin America,Eastern and Central Europe, North Africa, Turkey, Asia, Iran, andthe South Pacific. Volume II focuses on new developments inPIDs, insights into PID pathophysiology, and PIDs in India and theMiddle East. NOTE: Annals volumes are available for sale as individualbooks or as a journal. For information on institutional journalsubscriptions, please visit http://ordering.onlinelibrary. wiley.com/subs.asp?ref=1749-6632&doi=10.1111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciencesdirectly to place your order (www.nyas.org). Members of the NewYork Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspxfor more information about becoming a member.